Following up on 2019´s focus on “Overcoming Sickle Cell Disease – Power of the Collective Voice”, Africa has seen steady increase in cross-border cross-organization collaborations and projects across the region and beyond. The theme of the 2nd African Congress on Sickle Cell Disease will review the current state of SCD and explore future perspectives with challenges and priorities to sickle cell disease prevention and control at the local, regional and global level. The congress will be both scientific and technical, with focus dialogues, speeches and interactive sessions featuring government officials, private sector and sickle cell experts, researchers and academia, advocates, patient and caregivers engaged in exploring evidence-informed, innovative ways to address the challenges and further sickle cell control.